Stellenbezeichnung: Postdoc/Scientist „Functional single cell genomics using pertubations in ex vivo lung tissue slice cultures“ (f/m/x)
Arbeitsort / Location: München, Bayern
Job Beschreibung: Offer Description
Area of research:
Scientific / postdoctoral posts
Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.
The Schiller lab researches how cells are wired together into circuits and thereby influence each other in lung health and disease.
We are looking for a highly motivated postdoctoral scientist (f/m/x) to join the Schiller lab ( ; Pubmed: Schiller HB) at the Institute of Lung Health and Immunity / Comprehensive Pneumology Center.
Lung disease is the 2nd most common cause of death globally. Approximately 7.4% of the human population are currently affected by a chronic lung disease, making respiratory disease a major cause of morbidity and mortality globally. We aim to advance pulmonary precision medicine by reconstructing molecular and cellular circuits in the human lung in order to develop preventive and regenerative therapies.
We aim to leverage the emerging concept of the `lab in a loop´, which builds on accelerating the iteration of experimental perturbations of tissues from healthy donor lungs as well as diseased explant lungs in the lab with AI based model building (e.g. gene regulatory networks and cell-cell communication). Overall, we work on the vision of generating a human lung cell perturbation atlas that will be used to train a generative AI foundation model of cells in the human lung (collaboration with Theis lab at Helmholtz Munich). To enable this we have established single cell genomic readouts of perturbations in human precision cut lung slices (see .
A large number of cellular/pathway perturbations in human lung tissue will enable generative AI and ultimately the resulting foundational model will be used to make predictions and capture the regulatory logic of cell circuits in the human lung from the latent space embeddings. In combination with integration of in vivo patient data (electronic health records + multimodal single cell omics) we anticipate that this approach will enable us to recognize specific disease states on the tissue level and predict molecular targets for reverting disease phenotypes. This platform will thus hold the potential to revolutionize and massively accelerate therapeutic and preventative strategies for lung diseases.
Postdoc/Scientist „Functional single cell genomics using pertubations in ex vivo lung tissue slice cultures“ (f/m/x)102104
- Implement and benchmark multiplexing methods for massive scaling of single cell/nuclei genomics in perturbed human precision cut lung slices (hPCLS)
- Genetic and pharmacological perturbations in hPCLS (e.g. siRNA, inhibitors, AAV-mRNA technology)
- Integration of WGS/GWAS with single cell multiome (scATAC/scRNAseq) from perturbations in diseased explant lungs
- Close collaboration with computational biologists on analysis of perturbation data
- Daily supervision of graduate students and lab technicians
- Project team management and scientific paper writing
- You have a PhD degree in the life sciences or a related field
- Expertise in (single cell) omics techniques, systems biology and basic bioinformatic data analysis (R/Python) is required
- Expertise in advanced molecular biology, viral transduction, and/or high throughput phenotypic assay development is beneficial
- Prior experience with tissue culture or other complex ex vivo models (e.g. organoids) is beneficial
- You are proficient in written and spoken English and have excellent interpersonal and analytical skills
What we offer you
flexible working hours & working-time models
continuous education and training
30 days annual leave
on-site health management service
home office options
on-site nursery & holiday care
elder care company pension scheme discounted public transport ticket
Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.
Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to two years, under certain circumstances an extension can be arranged.
To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.
**Interested?**If you have further questions, simply contact Herbert Schiller, , who will be happy to be of assistance. **Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Health and Immunity
Comprehensive Pneumology Center (CPC)
Total E-Quality Award for excellent gender equality policy for women and men: Helmholtz Munich is particularly committed to promoting professional equality between women and men. It therefore aims to increase the proportion of the underrepresented sex in the respective field. Helmholtz Munich is part of the Helmholtz Association, Germany’s largest scientific organization. Altogether 43.000 people currently work in its 18 scientific-technical and biological-medical research centers. The Association’s annual budget amounts to around 5 billion Euros.
This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany’s largest scientific organisation.
Website for additional job details
Number of offers available 1 Company/Institute Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt Country Germany City München
Where to apply Website
Ingolstädter Landstraße 1 Postal Code
+49 89 3187-0 Fax
+49 89 3187-3322